TB Bacteria use Iron to Survive

The tuberculosis (tb) bacteria kill two people every three minutes. The bacteria uses iron from the human body to survive. But the mechanism by which they source the iron was not known. Researchers from the University of Hyderabad have recently cracked the mechanism.

The Tuberculosis (tb) bacteria kill two people every three minutes. The bacteria uses iron from the human body to survive. But the mechanism by which they source the iron was not known. Researchers from the University of Hyderabad have recently cracked the mechanism. Their research paves the way for new medicines to treat the disease better.

The tb pathogen sources its iron through molecules called siderophores, which have high affinity for iron. First, the pathogens release these molecules, which extracts iron from human cells, leaving them iron-scarce. The molecules are then transported back to the pathogen, which synthesizes the iron to sustain and grow at the cost of the host. These actions are dependent on two proteins that help complete the transportation cycle of siderophores. Blocking this transportation through medicines can be a breakthrough to cure tb. First, it will stop the iron uptake and secretion. Since there will be no export pathway for siderophores, it will extract iron from the microbe itself. Continue reading »

Tigers that recently killed people in India

Close to the foothills of the Himalaya four tigers ventured out of forests and killed 11 people in the past five months. The killings have challenged the official understanding of man-eaters. Unlike the man-eaters of Kumaon Jim Corbett wrote about, these were not rendered incapable of hunting by either old age or injury. All four tigers were young; two were adolescents.

The 10-year-old tiger - they usually life for 14-15 years in the wild-in Corbett National Park killed Bhagwati Devi of Dhikuli village in the buffer zone of the park on February 6 when she went into the forest to collect firewood. The villagers said the tiger attacked the 50-year-old from behind as she sat collecting wood. Following protests by people, the chief wildlife warden of Uttarakhand issued orders to kill or catch the “man-eater”. The forest department trapped the animal and sent it to a zoo in Nainital on February 10.

Bhagwati Devi’s husband B C Nainwal, however, does not blame the tiger. “It is the policies of the government that made the tiger a victim of public ire,” he said. “The tiger was roaming near Dhikuli for four-five months. The main reason was elephant safaris by resorts here. They are known to throw meat in front of the tiger to increase the sighting of the big cat.” Continue reading »

Who’s encroaching? Noida eyes the Yamuna floodplain

Noida eyes the Yamuna floodplain
About 1,000 migrants lost their livelihood when their huts and crops on the Yamuna floodplain near the Delhi-Uttar Pradesh border were razed in December. The Uttar Pradesh Irrigation Department carried out the operation on a 25-hectare (ha) patch of the floodplain at Nayabaans village in Noida so that it can transfer the land to Noida for development.

The settlers were from Uttar Pradesh and Bihar. They grew vegetables, flowers, wheat and rice on the land rented from people who once held land lease given by the irrigation department. Pappu of Kaimur district in Bihar had rented about 6 ha at Nayabaans close to the Okhla Bird Park and DND flyway for Rs 6,000 per hectare for a year. While he farmed, his younger siblings studied in a makeshift school. He lost his month-old vegetable crop and has nowhere to go.

“They just came in the evening and trampled all over the vegetables and flooded the fields. Had they at least given us a notice we would not have sown crops. I had invested Rs 15,000-20,000 on wheat.”

said Sauraj Singh Kashyap of Hapur in Uttar Pradesh. H C Malhotra, a member of literacy organization Gyan Jyoti Vidyalaya, which set up the makeshift school in the area, said “These people have not made permanent structures on the riverbed. They were merely making a living out of agriculture.” Continue reading »

[Nuclear Power] Stepping on a minefield

As nuclear waste maims people, India plans to generate more.

INDIA intends to increase the share of nuclear power from 3.1 per cent of its total energy generation to 25 per cent by 2050. Six nuclear power reactors are under construction and eight are in the pipeline. While the country plans to expand mining of uranium to feed the reactors, a yet-to-be-released study by the environmental group “Toxics Link” pointed out that it lacked knowledge about handling nuclear waste; the existing uranium mines do not follow requisite safety methods.

Most uranium is mined in Jadugoda in East Singhbum district and three other places in Jharkhand. The ore in Indian mines contains a low percentage (0.042-0.051 per cent) of the mineral, except in Meghalaya. The problem with low-grade ore is that extracting a small amount of concentrated uranium generates a large amount of waste. The ore grade is high in Meghalaya but an onslaught of rains makes the terrain almost inaccessible for six months in a year.

The Uranium Corporation of India Limited (UCIL) plans to invest about Rs 31 billion to set up new mines and processing plants in Jharkhand, Andhra Pradesh and Meghalaya as part of the eleventh plan. “The proposed mine at Kadapa in Andhra Pradesh involves extraction of 3,000 tonnes of uranium per day from underground mines spread over 879 hectares,” said the study done from August to November. Quoting members of the non-profit Mines, Minerals and People, the study said for a uranium concentration of 0.039 per cent, the waste to be disposed of would amount to nearly a million tonnes per year. Continue reading »

Current trends of Renewable Energy

Solar photovoltaics is the fastest growing area in the energy sector. Of the US $71 billion invested in renewables worldwide in 2007, 30 per cent was in solar PV. According to market analysts, between 2007 and 2011, this industry is poised to grow at a whopping 73 per cent. By March 2007, India had 120 mw of installed PV capacity. However, less than 2.5 MW is generated by grid-connected solar power plants. The rest is generated through stand-alone systems like solar street lighting (about 70,474), home lighting (4,02,938) and solar lanterns (6,70,059).

The government has several schemes supporting and subsidizing various kinds of solar power systems.The emphasis is on encouraging manufacturing and industry rather than on installations as solar PV manufacturing is capital intensive.

Through the special incentive package scheme, the government offers capital subsidies to state-of-the-art semiconductor manufacturing and related units, including solar PV. Eligible semiconductor “fab” projects must have a net present value of at least Rs 2,500 crore. The subsidy available is 25 per cent of the capital expenditure; it is 20 per cent for projects in a special economic zone. The response was good. “Most of the manufacturers who have applied under the scheme want to invest in photovoltaic technology. Proposals roughly worth Rs 1,40,000 crore from 14 manufacturers are lying with the ministry of which 12 are photovoltaic manufacturers” said K S Chari, director in the Union Ministry of Communications and Information Technology, the nodal ministry. Most of the proposals have been forwarded to a technical evaluation committee and decision is expected “shortly”. Continue reading »

[India] Asbestos, endosulfan escape blacklist

India blocked export restrictions on them at Rotterdam Convention.
India yet again played spoilsport by preventing chrysotile asbestos and endosulfan from being included in Annex III of UN’s Rotterdam Convention that brands them hazardous. Had the two been included in Annex III, it would have made mandatory for countries to take a Prior Informed Consent, or PIC, before exporting them to other countries.

Of the three substances listed for PIC at the fourth meeting of the Conference of Parties (cop-4) to the Rotterdam Convention, only tributyltin was listed at the meeting held from October 27 to 31 in Rome. While seven countries opposed asbestos from being blacklisted, in case of endosulfan only India was responsible for its exclusion.

“India was put in a spot when country after country joined in accusing it for its entrenched position of not allowing the listing of endosulfan, a highly toxic pesticide,”

said Madhumita Dutta of Chennai-based advocacy group The Other Media. Continue reading »

Corporal lab - Clinical trials sustain Ahmedabad’s Riot Victims

Clinical trials sustain Ahmedabad’s riot victims

When her husband took chronically ill after communal riots drove them to Juhapura, a ghetto on the outskirts of Ahmedabad, poverty made life seem unmanageable. Free will then became a matter of Rs 8,000 for 40-year-old Zainab Bi. For a sum like that she was willing to swallow an unknown pill once in three months. It wasn’t much they were asking for really, so she gladly gave her thumb impression on the dotted line.

For companies researching new drugs the thumb impression was proof that Bi submitted herself to the experiment of her own free will. It was far more expensive to have such proof in countries where the multinational drug companies that sponsored the research had their headquarters. They were far more cumbersome, involved lengthy documentation and rigorous insurance plans. Clinical research organizations (cros) made the task far easier for these companies by carrying out their research in the ghettoes of India’s big cities. Drug trial was far less daunting; and inexpensive. People were more than willing to offer their bodies for bio-chemical experimentation. The official guidelines warned against monetary inducement. Continue reading »

Losing Touch - Sabarmati Embankment project Ignores warnings, Precedents

Sabarmati embankment project ignores warnings, precedents

Construction of an embankment along the 10-km stretch of the Sabarmati has begun in Ahmedabad despite warnings that it may hamper natural drainage in the city and that its design is inherently flawed. The 8.5-m-high embankment is part of the Sabarmati Riverfront Development Project, the first in India where the river will be squeezed to yield land for commercial, residential and open spaces. Project planners expect to recover the cost by selling this real estate.

The project’s Environment Impact Assessment (eia) report, however, said that embanking the Sabarmati would not just prevent drainage and “cordon the river away from the people”. It would also increase its speed, thereby increasing erosion that would affect the stability of the retaining walls and bridges. The report was prepared by the Ahmedabad-based Centre for Environmental Planning and Technology and the Gujarat Ecology Commission in Vadodara. Project designer hcp Design and Project Management Pvt Ltd, formerly called Environmental Planning Collaborative, said drains from low-lying areas would be directed to the river through underground channels. The riverfront project was proposed in 1997 to develop the banks into recreational zones. Continue reading »